Due to the ability of stem cells to differentiate into any cell type, their potential use in various cell- based therapeutic strategies makes more sense. The appropriate combination of surgeries, cell- based therapies, and retaining network-circuits long-term treatments could be achieved with various objectives like forming neurons and glial cells, functional recovery, and pain management. Exosomes offered along with mesenchymal stem cells are responsible for immune regulation post-stem cell therapy. This offers appropriate protection to the newly formed neurons, by serving as the first line of defense against injury-induced tissue loss, further contributing to the improved neurological outcome.